Results of a small Johns Hopkins Children’s Center study show that hospitalized children given high-dose IV infusions of the antibiotic vancomycin to treat drug-resistant bacterial infections face an increased risk for kidney damage — an often reversible but sometimes serious complication….
Microcapsule Eliminates Toxic Punch of Experimental Anti-Cancer Drug
Johns Hopkins researchers have developed a sugar-based molecular microcapsule that eliminates the toxicity of an anticancer agent developed a decade ago at Johns Hopkins, called 3-bromopyruvate, or 3BrPA, in studies of mice with implants of human pancreatic cancer tissue. The encapsulated…
Study Shows Serotonin Can Increase Risk of Drug Addiction
A study by Sarah Bradbury, who graduates with a PhD in Psychology next week, shows that the development of drug addiction is related to brain levels of serotonin—a chemical created by the human body that is responsible for maintaining mood balance….
Virus Discovery Could Impact HIV Drug Research
A research team led by Portland State University biology professor Ken Stedman has unlocked the structure of an unusual virus that lives in volcanic hot springs. The discovery could pave the way for better drugs to treat Human Immunodeficiency Virus (HIV),…
Increased Dosing of Malaria Drug in Children May Lower Infection Risk
Piperaquine is a long-acting malaria drug that kills residual parasites and decreases the risk of reinfection. A study led by Uppsala University researcher Martin Bergstrand shows that increasing the dose used in children could potentially decrease the yearly incidence of malaria…
Drug Combination Shows Promise As Powerful Breast Cancer Treatment
The uncontrolled growth of cancer cells arises from their ability to hijack the cell’s normal growth program and checkpoints. Usually, after therapy, a second cancer-signaling pathway will open after the primary one shuts down — creating an ingenious escape route for…
EBC 46 Human Trials Destroy Tumors
Scientists at QIMR Berghofer Medical Research Institute have used an experimental drug produced from the seeds of a rainforest plant to cure solid cancer tumors in preclinical trials. The study led by Dr. Glen Boyle at QIMR Berghofer’s Cancer Drug Mechanisms…
Experimental Drug Provided to Dallas Ebola Patient
A North Carolina drugmaker is providing its experimental antiviral drug to a Dallas patient being treated for Ebola, an emergency step authorized by the Food and Drug Administration. Officials at Texas Health Presbyterian Hospital said Monday that their patient, Thomas Eric…
Vivolux Cancer Drug Receives FDA Clearance for Clinical Study
Vivolux, a pharmaceutical company specialized in cancer treatment, announced that the FDA has granted clearance to proceed with VLX1570 Clinical Trial phase 1/2 for treatment against relapsed and/or refractory multiple myeloma. Researchers at Vivolux have discovered a novel cancer drug target…