{"id":6990,"date":"2017-01-31T11:30:56","date_gmt":"2017-01-31T16:30:56","guid":{"rendered":"http:\/\/5d2.b96.myftpupload.com\/?p=6074"},"modified":"2026-03-31T14:37:31","modified_gmt":"2026-03-31T21:37:31","slug":"blood-pressure-genes","status":"publish","type":"post","link":"https:\/\/fomatmedical.com\/es\/blogs-updates\/blood-pressure-genes\/","title":{"rendered":"M\u00e1s de 100 nuevos genes relacionados con la presi\u00f3n arterial podr\u00edan proporcionar objetivos para el tratamiento de la hipertensi\u00f3n."},"content":{"rendered":"

At FOMAT, cardiovascular research is one of our core therapeutic areas and hypertension is among the most prevalent conditions we encounter across our patient communities. The discovery of 107 new gene regions linked to blood pressure represents a significant step toward precision medicine approaches that could one day allow doctors to intervene before hypertension even develops. Understanding the genetic basis of blood pressure also helps inform how future cardiovascular trials are designed and who should be prioritized for enrollment. Here is what this large-scale genetic study found:<\/p>\n

Scientists have found 107 new gene regions associated with high blood pressure, potentially enabling doctors to identify at-risk patients and target treatments. (Blood Pressure Genes)<\/span><\/p>\n

The study, led by Queen Mary University of London (QMUL) and Imperial College London, suggests that by using genetic testing, doctors could target medication to certain high blood pressure (hypertension) patients and advise on appropriate lifestyle changes to reduce a risk of heart disease and stroke. The findings are published in\u00a0Nature Genetics<\/em><\/a>.<\/p>\n

Hypertension affects around one in three (15 million) adults in the UK, and is a leading risk factor for heart disease, stroke and death worldwide. It is caused by a complex interplay between genetics and lifestyle factors such as diet, weight, alcohol consumption, and exercise.<\/p>\n

The researchers tested 9.8 million genetic variants from 420,000 UK Biobank participants and cross-referenced these with their blood pressure data. Of the 107 new gene regions, many were expressed in high levels in blood vessels and cardiovascular tissue, and could be potential new drug targets for hypertension treatments.<\/p>\n

The team also developed a genetic \u2018risk score\u2019 by linking health and hospital data from UK Biobank participants with their blood pressure genetics, and showed that the score could be used to predict increased risk of stroke and coronary heart disease.<\/p>\n

\"Treating<\/p>\n

The higher a patient\u2019s risk score, the more likely they were to have high blood pressure by the age of 50. Those on the top end of the risk scale were likely to have 10mmHg higher blood pressure than patients with lower risk scores. For every 10mmHg a person\u2019s blood pressure is above normal, the risk of heart disease and stroke is increased by around 50 per cent or more.<\/p>\n

If such a genetic risk score could be measured in early life, it might be possible to take a \u2018personalised medicine\u2019 approach to offset a person\u2019s high risk of stroke and heart disease. This could involve lifestyle interventions such as changing sodium and potassium intake, weight management, reducing alcohol consumption and increasing exercise.<\/p>\n

Professor Mark Caulfield, co-lead author of the study from QMUL’s\u00a0William Harvey Research Institute<\/a>, said: \u201cFinding 107 new genetic regions linked to blood pressure almost doubles the amount of genes we can evaluate to target for drug treatment. These exciting genetic regions could provide the basis for new innovative preventative therapies and lifestyle changes for this major cause of heart disease and stroke.\u201d<\/p>\n

Professor Paul Elliott, co-lead author of the study and Chair in Epidemiology and Public Health Medicine at Imperial\u2019s School of Public Health, said: \u201cUltimately, blood pressure in the general UK population is too high, and we encourage everyone to maintain healthy lifestyles by eating properly and exercising enough, as this will reduce the risk of all sorts of diseases. However, our new findings may help doctors to identify earlier those who are most at risk of high blood pressure in mid-life and intervene to prevent that occurring.\u201d<\/p>\n

Genetic testing to provide risk scores is not available widely for any of the common diseases so far, but it could one day become routine. Professor Elliott added: \u201cWe cannot help our genetic makeup, but we can help our lifestyles and, in future, we may be able to alter our lifestyles while knowing whether we are at a genetic advantage or disadvantage. Doctors might eventually be able to determine a child\u2019s genetic risk of diseases such as high blood pressure, diabetes, and maybe even cancer, so that they can live well enough to try to counteract the genetic input.\u201d<\/p>\n

First author Dr Helen Warren from QMUL said: \u201cThis analysis highlights the benefits of using very large studies, such as UK Biobank, with high quality data where all participants have had measurements done in exactly the same way, to enable the discovery of many new genetic signals associated with raised blood pressure.\u201d<\/p>\n

For 10 years, UK Biobank has gathered a wealth of high quality information from hundreds of thousands of people across the country. Participants have donated blood, urine and saliva samples, provided detailed health, lifestyle and environment information, and agreed to allow the Biobank to follow their GP and hospital records throughout life.<\/p>\n

Minister for Public Health and Innovation, Nicola Blackwood said: \u201cHypertension is a serious public health concern, affecting millions across the country- and this research has great potential. It offers a deeper understanding of the genetics behind this condition and will help us shape future treatments. The UK is a world leader in health research and this kind of work is exactly why the Department of Health continues to give the NIHR \u00a31bn a year.\u201d<\/p>\n

The study was supported by the National Institute for Health Research. UK Biobank was established by the Wellcome Trust, Medical Research Council, Department of Health and Scottish Government and has also received funding from the Welsh Assembly Government, British Heart Foundation and Diabetes UK.<\/p>\n","protected":false},"excerpt":{"rendered":"

En FOMAT, la investigaci\u00f3n cardiovascular es una de nuestras principales \u00e1reas terap\u00e9uticas, y la hipertensi\u00f3n es una de las afecciones m\u00e1s frecuentes que observamos en nuestras comunidades de pacientes. El descubrimiento de 107 nuevas regiones gen\u00e9ticas relacionadas con la presi\u00f3n arterial supone un paso importante hacia\u2026<\/p>","protected":false},"author":3,"featured_media":53198,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[968,921,984],"tags":[1075,1012,1160,1161],"class_list":["post-6990","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blogs-updates","category-news","category-research-studies","tag-blood","tag-diabetes","tag-hypertension","tag-pressure"],"acf":[],"_links":{"self":[{"href":"https:\/\/fomatmedical.com\/es\/wp-json\/wp\/v2\/posts\/6990","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fomatmedical.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fomatmedical.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fomatmedical.com\/es\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/fomatmedical.com\/es\/wp-json\/wp\/v2\/comments?post=6990"}],"version-history":[{"count":2,"href":"https:\/\/fomatmedical.com\/es\/wp-json\/wp\/v2\/posts\/6990\/revisions"}],"predecessor-version":[{"id":73153,"href":"https:\/\/fomatmedical.com\/es\/wp-json\/wp\/v2\/posts\/6990\/revisions\/73153"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fomatmedical.com\/es\/wp-json\/wp\/v2\/media\/53198"}],"wp:attachment":[{"href":"https:\/\/fomatmedical.com\/es\/wp-json\/wp\/v2\/media?parent=6990"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fomatmedical.com\/es\/wp-json\/wp\/v2\/categories?post=6990"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fomatmedical.com\/es\/wp-json\/wp\/v2\/tags?post=6990"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}