{"id":3616,"date":"2015-02-04T13:50:16","date_gmt":"2015-02-04T18:50:16","guid":{"rendered":"https:\/\/fomatmedical.com\/?p=3616"},"modified":"2015-02-04T13:50:16","modified_gmt":"2015-02-04T18:50:16","slug":"allergic-drug-reactions-traced-single-protein","status":"publish","type":"post","link":"https:\/\/fomatmedical.com\/es\/blogs-updates\/allergic-drug-reactions-traced-single-protein\/","title":{"rendered":"Reacciones al\u00e9rgicas a medicamentos atribuidas a una sola prote\u00edna"},"content":{"rendered":"

Every day in hospitals around the world, patients suffer painful allergic reactions to the medicines they are given. The reactions, known as pseudo-allergies, often cause patients to endure itchiness, swelling and rashes as an unwanted part of their treatment plan. The reactions can be so severe they may stop patients from taking their needed medications and sometimes can even prove fatal. It\u2019s never been shown conclusively what triggers these allergic reactions\u2014until now.<\/p>\n

\u201cWe are in the very early stages but we now understand how these pseudo-allergies are happening,\u201d said Marianna Kulka, an adjunct assistant professor in the University of Alberta\u2019s Department of Medical Microbiology and Immunology and project group leader with the National Institute for Nanotechnology. \u201c<\/em>This is a very large step forward in many ways.\u201d<\/p>\n

In a study published in the December edition of the journal Nature, researchers from the U of A’s Faculty of Medicine & Dentistry and Johns Hopkins University identified a single protein as the root cause of allergic reactions to drugs and injections. They are now exploring ways to block the protein and reduce painful side effects caused by the reactions.<\/p>\n

\u201cThe drugs currently being used are to treat some very nasty diseases and they\u2019re very effective at that. But side effects are a huge problem. If we can avoid these side effects by finding a way to block this problematic protein, we can really design drugs that are effective and safe,\u201d<\/em> said Kulka, a co-author on the study.<\/p>\n

In their findings the researchers focused on reactions triggered by medicines prescribed for a number of conditions that range from prostate cancer to diabetes to HIV. These reactions are different from the allergic reactions caused by food or experienced by hay fever sufferers.<\/p>\n

\"Allergic<\/p>\n

The scientists tested lab models with and without a single protein\u2014named MRGPRB2\u2014on their cells. The lab models without the protein did not suffer negative effects despite being given drugs known to provoke reactions.<\/p>\n

Benjamin McNeil, a post-doctoral fellow at Johns Hopkins University and study co-author, said, \u201cIt\u2019s fortunate that all of the drugs turn out to trigger a single receptor\u2014it makes that receptor an attractive drug target.\u201d<\/p>\n

The researchers said if a new drug to block the protein receptor could be made, it would lessen the drug side-effects patients currently endure. Kulka believes with time, some painful reactions from medications can be avoided.<\/p>\n

\u201cBy understanding how they\u2019re happening we can really help to avoid some of the pitfalls of designing drugs that cause the pseudo-allergies. We\u2019ve got big plans in the future for trying to expand this [research] and better understand how this works.\u201d<\/em><\/p>\n

Source: University of Alberta<\/p>\n

Date:\u00a0February 4,\u00a02015<\/strong><\/p>\n

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Cada d\u00eda, en hospitales de todo el mundo, los pacientes sufren dolorosas reacciones al\u00e9rgicas a los medicamentos que se les administran. Estas reacciones, conocidas como pseudoalergias, suelen provocar picaz\u00f3n, hinchaz\u00f3n y erupciones cut\u00e1neas, que los pacientes deben soportar como parte indeseada de su plan de tratamiento. El...<\/p>","protected":false},"author":3,"featured_media":22189,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[968,1091,1092],"tags":[940],"class_list":["post-3616","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blogs-updates","category-diseases","category-drug-discovery-and-research","tag-medical-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/fomatmedical.com\/es\/wp-json\/wp\/v2\/posts\/3616","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fomatmedical.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fomatmedical.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fomatmedical.com\/es\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/fomatmedical.com\/es\/wp-json\/wp\/v2\/comments?post=3616"}],"version-history":[{"count":0,"href":"https:\/\/fomatmedical.com\/es\/wp-json\/wp\/v2\/posts\/3616\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fomatmedical.com\/es\/wp-json\/wp\/v2\/media\/22189"}],"wp:attachment":[{"href":"https:\/\/fomatmedical.com\/es\/wp-json\/wp\/v2\/media?parent=3616"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fomatmedical.com\/es\/wp-json\/wp\/v2\/categories?post=3616"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fomatmedical.com\/es\/wp-json\/wp\/v2\/tags?post=3616"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}